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In the last 10 years, Baylor-Uganda has progressively built a solid research foundation through national and international research collaborations with international institutions of higher learning, international research bodies and multi-lateral research networks to investigate HIV treatment;

relation between HIV and other non-communicable diseases, sexual behavioral changes in children as they transition through the various age strata, trends in opportunistic infections, patient survival, nutrition outcomes among other research questions raised during the care.
The organization maintains high level research regulatory and compliance systems that meet internationally acceptable standards for conducting research. Clearances for ongoing and new research projects are attained from Uganda National Council for Science and Technology (UNCST) for all research projects and National Drug Authority (NDA) for clinical Trials while working closely with Institutional Review Bodies, Research and ethics Currently, there are 10 ongoing studies namely; IMPAACT P1115 which is Very Early Intensive Treatment of HIV-Infected Infants to Achieve HIV Remission, Collaborative African Genomics Network Study (CAFGEN) which aims to integrate genetic and genomics technologies to probe host genetic factors that influence progression of HIV and HIV-TB infection in sub-Saharan African children, TITOs Study which aims to determine the burden of latent and active TB and determine the treatment outcomes among HIV infected children in Uganda, GUMBA Study, GENEFA, PHIRMA, CAMP Study, ODYSSEY Study among others. During the year, Baylor-Uganda and the partners involved in the Collaborative African Genomics Network Study (CAfGEN) launched the first ever Genomics Adventure comic book with the aim of creating community awareness on the role of genetics and health.

 

MANUSCRIPTS PUBLISHED USING BAYLOR-UGANDA DATA (STUDIES & GENERAL CARE)

NO FIRST AUTHOR TITLE DATE PUBLISHED JOURNAL  
1   Multi-country validation of SAMBA – A novel molecular point-of- care test for HIV-1 detection in resource–limited setting 6/9/2017 JAIDS Journal of Acquired Immune Deficiency Syndromes
1   Multi-country validation of SAMBA – A novel molecular point-of- care test for HIV-1 detection in resource–limited setting 6/9/2017 JAIDS Journal of Acquired Immune Deficiency Syndromes
2 Rogers Ssebunya Antiretroviral therapy initiation within seven days of enrolment: outcomes and time to undetectable viral load among children at an urban HIV clinic in Uganda 19-Jun-17 BMC Infectious Diseases
3 Jonathan Izudi Quality Improvement Interventions for Nutritional Assessment among Pregnant Mothers in Northeastern Uganda Volume 2017 (2017), Article ID 8036535, 6 pages BioMed Research International
4 Adeodata Kekitiinwa Virologic Response to First-line Efavirenz- or Nevirapine-based Antiretroviral Therapy in HIV-infected African Children. 2017 Jun;36(6):588-594 Pediatr Infect Dis J
5 Busisiwe C Mlotshwa The collaborative African genomics network training program: a trainee perspective on training the next generation of African scientists 2017 Apr 6. Epub 2017 Apr 6 Genet Med
6 Adeodata Kekitiinwa Virologic Response to First-Line Efavirenz- or Nevirapine-Based Anti- Retroviral Therapy in HIV-Infected African Children. 2016 Dec 23. Epub 2016 Dec 23 Pediatr Infect Dis J
7 Andrew J Prendergast Reduced bacterial skin infections in HIV-infected African children randomized to long-term cotrimoxazole prophylaxis. 2016 Nov;30(18):2823-2829 AIDS
8 Adeodata Kekitiinwa Acceptability of lopinavir/r pellets (minitabs), tablets and syrups in HIV- infected children. 2016 29;21(7):579-585. Epub 2016 Apr 29. Antivir Ther
9 Angela M Crook Tuberculosis incidence is high in HIV-infected African children but is reduced by co-trimoxazole and time on antiretroviral therapy. 2016 Mar 23;14:50. Epub 2016 Mar 23 BMC Med
10 Veronica Mulenga Abacavir, Zidovudine, or stavudine as Paediatric tablets for African HIV-infected children (CH APAS-3): an open-label, parallel-group, randomised controlled trial. 2016 Feb 5;16(2):169-79. Epub 2015 Oct 5. Lancet Infect Dis
11 Jonathan Izudi Quality Improvement Interventions for Early HIV Infant Diagnosis in Northeastern Uganda. 2016 26;2016:5625364. Epub 2016 Dec 26 Biomed Res Int
12 Zikulah Namukwaya Use of peers, community lay persons and Village Health Team ( VHT) members improves six-week postnatal clinic (PNC) follow-up and Early Infant HIV Diagnosis (EID) in urban and rural health units in Uganda: A one-year implementation study. 2015 Dec 15;15:555. Epub 2015 Dec 15. BMC Health Serv Res
13 Jane Namuddu Availability of Human Immunodeficiency Virus Prevention Services in Secondary Schools in Kabarole District, Uganda. 2015 Aug 17;6(2):454. Epub 2015 Aug 17 J Public Health Afr
14 Alexander J Szuber t Pubertal development in HIV-infected African children on first-line antiretroviral therapy. 2015 Mar;29(5):609-18 AIDS
15 Mutsawashe Bwakura-Dangarembizi Prevalence of lipodystrophy and metabolic abnormalities in HIV- infected African children after 3 years on first-line antiretroviral therapy. 2015 Feb;34(2):e23-31 Pediatr Infect Dis J
16 Victor Musiime Anthropometric measurements and lipid profiles to detect early lipodystrophy in antiretroviral therapy experienced HIV-infected children in the CH APAS-3 trial. 2014 25;19(3):269-76. Epub 2013 Oct Antivir Ther
17 Victor Musiime The pharmacokinetics and acceptability of Lopinavir/ritonavir Minitab sprinkles, tablets, and syrups in African HIV-infected children. 2014 Jun;66(2):148-54 J Acquir Immune Defic Syndr
18 Charles Rotimi Research capacity. Enabling the genomic revolution in Africa. 2014 Jun;344(6190):1346-8 Science
19 Mutsawashe Bwakura-Dangarembizi A randomized trial of prolonged co-trimoxazole in HIV-infected children in Africa. 2014 Jan;370(1):41-53 N Engl J Med
20 Melissa Latigo Mugambi Do diagnosis delays impact receipt of test results? Evidence from the HIV early infant diagnosis program in Uganda. 2013 1;8(11):e78891. Epub 2013 Nov 1 PLoS One
21 Adeodata Kekitiinwa Routine versus clinically driven laboratory monitoring and first-line antiretroviral therapy strategies in African children with HIV (ARROW ): a 5-year open-label randomized factorial trial. 2013 Apr 7;381(9875):1391-403. Epub 2013 Mar 7. Lancet
22 Vincent J Tukei Virologic, immunologic and clinical response of infants to antiretroviral therapy in Kampala, Uganda. 2013 Mar 27;13:42. Epub 2013 Mar 27 BMC Pediatr
23 Adeodata Kekitiinwa Prospective long-term outcomes of a cohort of Ugandan children with laboratory monitoring during antiretroviral therapy. 2012 Aug;31(8):e117-25 Pediatr Infect Dis J
24 Thereza Piloya Lipodystrophy among HIV-infected children and adolescents on highly active antiretroviral therapy in Uganda: a cross sectional study. 2012 Jul 2;15(2):17427. Epub 2012 Jul 2 J Int AIDS Soc
25 Vincent J Tukei Safety and tolerability of antiretroviral therapy among HIV-infected children and adolescents in Uganda. 2012 Mar;59(3):274-80 J Acquir Immune Defic Syndr
26 Vincent J Tukei Prevalence and outcome of HIV-associated malignancies among children. 2011 Sep;25(14):1789-93 AIDS
27 Patricia Nahirya-Ntege Low incidence of Abacavir hypersensitivity reaction among African children initiating antiretroviral therapy. 2011 Jun;30(6):535-7 Pediatr Infect Dis J
28 Andrew Prendergast Hospitalization for severe malnutrition among HIV-infected children star ting antiretroviral therapy. 2011 Apr;25(7):951-6 AIDS
29 Zikulah Namukwaya The impact of maternal highly active antiretroviral therapy and short-course combination antiretroviral for prevention of mother-to-child transmission on early infant infection rates at the Mulago national referral hospital in Kampala, Uganda, January 2007 to May 2009. 2011 Jan;56(1):69-75 J Acquir Immune Defic Syndr
30 Victor Musiime Pharmacokinetics and acceptability of once- versus twice-daily lamivudine and Abacavir in HIV type-1-infected Ugandan children in the ARROW Trial. 2010 ;15(8):1115-24 Antivir Ther
31 Nicolas A Menzies Cost-effectiveness of routine rapid human immunodeficiency virus antibody testing before DN A-PCR testing for early diagnosis of infants in resource-limited settings. 2009 Sep;28(9):819-25 Pediatr Infect Dis J
32 Theodore Ruel Dynamics of T cell activation accompanying CD4 recover y in antiretroviral treated HIV-infected Ugandan children. 2009 Jun 19;131(3):410-4. Epub 2009 Mar 19. Clin Immunol
33 Theodore D Ruel HIV RNA suppression among HIV-infected Ugandan children with measles. 2008 Jun;48(2):225-7 June 2008 J Acquir Immune Defic Syndr
34 Ellen Hyun-Ju Lee Haemophilus influenzae type b conjugate vaccine is highly effective in the Ugandan routine immunization program: a case-control study. 2008 Apr 25;13(4):495-502. Epub 2008 Feb 25 Trop Med Int Health
35 Anne F Gasasira High risk of neutropenia in HIV-infected children following treatment with Artesunate plus amodiaquine for uncomplicated malaria in Uganda. 2008 Apr;46(7):985-91 Clin Infect Dis
36 Mark M Kabue Growth in HIV-infected children receiving antiretroviral therapy at a pediatric infectious diseases clinic in Uganda. 2008 Mar;22(3):245-51 AIDS Patient Care STDS
37 Crowley S Clinical management of HIV infection in children. 2007 Sep;2(5):410­5. doi: 10.1097/COH.0b013e3282ddedf5 Curr Opin HIV AIDS
38 Kekitiinwa Adeodata Differences in factors associated with initial growth, CD4, and viral load responses to ART in HIV­infected children in Kampala, Uganda, and the United Kingdom/Ireland 2008 Dec 1;49(4):384­92. doi: 10.1097/QAI.0b013e31818cdef5 J AcquirImmuneDefic Syndr
39 A. Sarah Walker Mortality in the Year Following Antiretroviral Therapy Initiation in HIV-Infected Adults and Children in Uganda and Zimbabwe CID 2012:55 (15 December) HIV/AIDS
40 Kasirye P Pharmacokinetics of antiretroviral drug varies with formulation in the target population of children with HIV­1. 2012 Feb;91(2):272­80. doi: 10.1038/clpt.2011.225. Epub 2011 Dec 21 ClinPharmacolTher.
41 Musiime V Pneumococcal disease: the leading cause of bacteraemia among children starting ART in Uganda and Zimbabwe 2013 Aug;32(8):856­862. Pediatr Infect Dis JUNAIDS Science
42 Nabukeera­BarungiN Adherence to antiretroviral therapy in children attending Mulago Hospital, Kampala 2007 Jun;27(2):123­31 AnnTropPaediatr
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